Keynotes Guillaume Hautbergue, PhD Affiliation: Department of Neuroscience, The University of Sheffield (UK) Title: GRASPSTM: A novel translatome technology to identify functional consequences of widespread RNA dysregulation in neurodegeneration Mario Guarracino, PhD Affiliation: Istituto di Calcolo e Reti ad Alte Prestazioni, Napoli (Italy) Title: Computational identification and annotation of alternative splicing Hiroshi Okamoto, PhD Affiliation: Kanazawa University (Japan) Title: Functionally distinct ryanodine receptor variants generated by alternative splicing using GG/AG intron Woan-Yuh Tarn, PhD Affiliation: Institute of Biomedical Sciences, Academia Sinica (Taiwan) Title: RBM4 promotes neuronal cell differentiation by modulating alternative splicing of signaling factors Ruth Sperling, PhD Affiliation: Department of Genetics, The Hebrew University of Jerusalem (Israel) Title: Supraspliceosomes a General Multi Fuctional Machine for the Processing of pre mRNA in the Cell Nucleus Dr. Anthony Schweitzer Affiliation: Affymetrix Expression Business Unit, Thermo Fisher Scientific (USA) Title: Uncovering Biomarkers Deep within the Complex Transcriptome and Considerations on the depth of sequencing required Dr. Franco Pagani Affiliation: Human Molecular Genetics, International Centre for Genetic Engineering and Biotechnology (Italy) Title: Structural requirement of modified U1 core spliceosomal RNA particles for therapeutic activity Dr. Peter Kloetzel Affiliation: Institut fur Biochemie Charité, Uniiversitätsmedizin Berlin (Germany) Title: Neuronal activity regulates splicing of retained intron-containing transcripts