Oral Contributions

Dr. Marcella Vacca

Affiliation: Institute of Genetics and Biophysics-CNR (Italy)
MeCP2 regulates alternative splicing in microglia

Dr. Marta Milo

Affiliation: Department of Biomedical Science, University of Sheffield (UK)
Title: Methods for identification of Alternative Splicing in RNA-Seq data analysis

Dr. Robin Fahraeus

Affiliation: Equipe Labellisée la Ligue Contre le Cancer, Inserm UMR1162, Université Paris 7, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010 Paris (France)
Antigenic peptides for the MHC class I pathway are synthesized from non-spliced mRNAs

Dr. Maayan Salton

Affiliation: Biochemistry and Molecular Biology Department, The Institute for Medical Research Israel-Canada, The Hebrew University Faculty of Medicine, Jerusalem (Israel)
Title: Epigenetic regulation of alternative splicing in health and disease

Dr. Jochen Reiss

Affiliation: Human Genetics, University Medicine Göttingen (Germany)
Title: The unusual genetics of molybdenum cofactor deficiency

Dr. Steve Wilton

Affiliation: Murdoch University (Australia)
Title: Therapeutic alternative splicing: an update on Duchenne muscular dystrophy exon skipping trials and other applications

Dr. Linda Bonen

Affiliation: Biology Department, University of Ottawa (Canada)
Title: Group II ribozyme introns and unusual splicing pathways in vivo

Dr. John Wang

Affiliation: Department of Biochemistry & Molecular Biology Michigan State University (USA)
Title: Galectins and pre-mRNA Splicing

Dr. Mugé Kuyumcu-Martinez

Affiliation: University of Texas Medical Branch (USA)
Title: Dysregulation of the splicing regulator RBFOX2 is an early event in cardiac pathogenesis of diabetes

Dr. Charles Lambert

Affiliation: Lab. Connective Tissues Biology, University of Liège (Belgium)
Title: Role of Cisplatin-induced Alternative Transcription and Splicing on Therapeutic Efficacy

Dr. Michelle Scott

Affiliation: Department of Biochemistry, Université de Sherbrooke (Canada)
Title: Alternative splicing regulation of pre-mRNA by small nucleolar RNAs

Dr. Megan Stevens

Affiliation: University of Bristol (UK)
Title: Manipulation of VEGF-A splicing using natural compounds as a potential therapeutic in diabetic nephropathy

Dr. Maria Spletter

Affiliation: Max Planck Institute for Biochemistry (Germany)
Title: The RNA-binding protein Arrest/Bruno regulates fibrillar myogenesis in Drosophila

Dr. Yu Zeng

Affiliation: The First Affiliated Hospital of China Medical University (China)
Title: A Cold Shock Protein RBM3 Attenuates Prostate Cancer “Stemness” by Inhibiting Splicing Variants of CD44

Dr. Jim Davie

Affiliation: University of Manitoba (Canada)
Title: H3K4 trimethylation: role in dynamic histone acetylation and pre-mRNA splicing

Dr. Elisabetta Castoldi

Affiliation: Department of Biochemistry, Maastricht University (The Netherlands)
Title: Antisense-based rescue of a F5 deep-intronic splicing mutation causing severe coagulation factor V deficiency

Dr. Jon Mujika

Affiliation: University of the Basque Country (Spain)
Title: Insights into protein splicing reaction steps by means of computational chemistry

Dr. Jie Wu

Affiliation: Stephenson Cancer Center, University of Oklahoma Health Sciences Center (USA)
Title: CDKN3 Transcripts in Lung Adenocarcinoma

Dr. Maryam Hamdollah-Zadeh

Affiliation: University of Bristol, School of Clinical Sciences, Academic Renal Unit (UK)
Title: Spliced isoform of Phospholipase A2 receptor in Membranous Nephropathy

Dr. Philip Potter

Affiliation: St. Jude Children’s Research Hospital, Chemical Biology and Therapeutics (USA)
Title: Tumor-specific modulation of alternative splicing by small molecules that target SF3B1

Dr. Maria Stella Carro

Affiliation: University of Freiburg, Department of Neurosurgery (Germany)
Title: Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

Dr. Beatrice Eymin

Affiliation: INSERM U1209 CNRS UMR5309 University Grenoble Alpes (France)
Title: SR proteins: their role in lung tumor progression and response to therapies

Dr. Laurent Delpy

Affiliation: Université de Limoges (France)
Title: Detrimental exon skipping of immunoglobulin transcripts in plasma cells: towards a new splicing therapy in the treatment of plasma cell disorders

Dr. Joanna Gracz

Affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences (Poland)
Title: Alternative splicing events in maize under herbicidal stress

Dr. Martin de Boer

Affiliation: Sanquin, University of Amsterdam (The Netherlands)
Title: Aberrant pre-mRNA splicing in immunodeficiencies

Dr. Jacek Majewski

Affiliation: McGill University (Canada)
Title: Chromatin and Splicing – Fact or Myth?

Dr. Rita Pancsa

Affiliation: MRC, Laboratory of Molecular Biology (UK)
Title: Protein coding regions with additional overlapping functions show a tendency to encode intrinsically disordered protein segments

Dr. Jesús Valdés

Affiliation: Departamento de Bioquímica, CINVESTAV (Mexico)
Title: Shortened C-terminus Confers Robustness to the Entamoeba histolytica Dbr1

Dr. Yann Fichou

Affiliation: Etablissement Français du Sang – Bretagne (France)
Title: Functional analysis of splice site variants: the example of blood group genes, and beyond

Dr. Jocelyn Côté

Affiliation: University of Ottawa (Canada)
Title: Targeting Protein Arginine MethylTransferase 1 (PRMT1) Alternative Splicing Regulation as a Novel Therapeutic Strategy for Breast Cancer

Dr. Bernard Jasmin

Affiliation: University of Ottawa (Canada)
Title: Staufen1 regulates splicing in DM1 skeletal muscle

Dr. Udo Conrad

Affiliation: IPK Gatersleben (Germany)
Title: Production of native-sized spider silk proteins and multimeric nanobodies synthesized in planta via intein-based multimerization

Dr. Carla Oliveira

Affiliation: Department of Biochemistry, University of Sao Paulo (Brazil)
Title: Characterization of an Inducible/Reversible DMPK 3’UTR (CTG)200 RNA Toxicity Mouse Model

Dr. Mani Mahadevan

Affiliation: University of Virginia, Department of Pathology (USA)
Title: Characterization of an Inducible/Reversible DMPK 3’UTR (CTG)200 RNA Toxicity Mouse Model

Dr. Liliana Florea

Affiliation: McKusick-Nathans Institute of Genetics Medicine and Department of Medicine, Johns Hopkins University School of Medicine (USA)
Title: Going deep: Ultra-sensitive computational detection of splicing variation from a single and from multiple RNA-seq samples

Dr. Hiromi Nishida

Affiliation: Biotechnology Research Center and Department of Biotechnogy, Toyama Prefectural University(Japan)
Title: DNA sequence bias between exonic and intronic regions causes nucleosome density difference in the filamentous ascomycetes Aspergillus

Dr. Eva Collakova

Affiliation: Virginia Tech (USA)
Title: Predicting RNA-binding motifs for splicing factors and generating co-splicing networks from temporal transcriptomics data

Dr. Liming Chen

Affiliation: Huazhong University of Science & Technology (China)
Title: Na+-coupled HCO3– transporters in renal physiology

Dr. Marcus Johansson

Affiliation: Umeå University (Sweden)
Title: The pre-mRNA retention and splicing complex controls the expression of RNA biogenesis factors

Dr. Thorben Sprink

Affiliation: Julius Kuehn- Institute, Institute for Biosafety in Plant Biotechnology (Germany)
Title: The splicing landscape of SPO11 in plants

Dr. Sebastian Oltean

Affiliation: University of Bristol (UK)
Title: Use of splicing-sensitive fluorescent reporters as tools for drug discovery

Dr. Francesco Catania

Affiliation: Institute for Evolution and Biodiversity, University of Munster (Germany)
Title: mRNA-associated processes and their influence on exon-intron structure in Drosophila melanogaster

Dr. Tim Schommartz

Affiliation: Heinrich Pette Institute, Leibniz Institute for Experimental Virology (Germany)
Title: Functional dissection of alternatively spliced herpesvirus genes by splice site mutagenesis

Dr. Martin Crespi

Affiliation: Institute of Plant Sciences Paris Saclay (France)
Title: A long non-coding RNA modulates alternative splicing in Arabidopsis

Dr. Raymond O’Keefe

Affiliation: The University of Manchester (UK)
Title: The role of splicing factor gene mutation in craniofacial disorders

Dr. Andre Dietrich

Affiliation: Institut de Biologie Moleculaire des Plantes, Universite de Strasbourg (France)
Title: Group II introns in plant mitochondria: characterization of novel splicing factors

Dr. Alan Cochrane

Affiliation: Department of Molecular Genetics, University of Toronto (Canada)
Title: Inhibition of Virus Replication by Small Molecule Alterations of Host RNA Processing

Dr. Arvydas Kanopka

Affiliation: Vilnius University, Institute of Biotechnology (Lithuania)
Title: Hypoxia and pre-mRNA splicing

Dr. Nathalie Vigneron

Affiliation: Ludwig Institute for Cancer Research (Belgium)
Title: Peptide splicing : a new aspect of proteasome function

Dr. Beatriz Fontoura

Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center (USA)
Title: Influenza Virus mRNA Trafficking Through Host Nuclear Speckles

Dr. Melanie Ohi

Affiliation: Department of Cell and Developmental Biology and Center for Structural Biology, Vanderbilt University Medical School (USA)
Title: Using cryo-electron microscopy to map conformational changes in the dynamic spliceosome

Dr. Willian Beck

Affiliation: College of Pharmacy, University of Illinois at Chicago (USA)
Title: Splicing Factors as Therapeutic Targets in Cancer

Dr. Luisa Romão

Affiliation: Instituto Nacional de Saúde Doutor Ricardo Jorge, Departamento de Genética Humana (Portugal)
Title: The interplay between mRNA translation and nonsense-mediated decay in transcripts with short open reading frames

Dr. Will Fairbrother

Affiliation: Brown University (USA)
Title: Disease-Causing Exonic Variations Frequently Affect Pre-mRNA Splicing

Dr. Mart Speek

Affiliation: University of Technology (Estonia)
Title: Transcriptional interference in human cells: exonization and intron retention

Dr. Sandra Fernandez

Affiliation: Ludwig-Maximilians- Universität (Germany)
Title: The role of the RNA-binding protein Staufen 2 in dendritic mRNA localization

Dr. Orit Shaul

Affiliation: Faculty of Life Sciences, Bar-Ilan University (Israel)
Title: The significance of splicing and specific intronic elements for intron-mediated enhancement

Dr. Lingfang Zeng

Affiliation: King’s College London (UK)
Title: HDAC3 unconventional splicing and endothelial-mesenchymal transition

Dr. Oren Ostersetzer

Affiliation: The Hebrew University of Jerusalem (Israel)
Title: Plant mitochondria group II introns splicing: A window into the evolution of the spliceosome

Dr. Lorea Blazquez

Affiliation: UCL Institute of Neurology (UK)
Title: Function and regulation of recursive splicing

Dr. Krzysztof Jagla

Affiliation: GReD Institute, INSERM, University of Clermont-Ferrand (France)
Title: Splice-dependent and splice-independent mechanisms underlying pathogenesis of Myotonic Dystrophy type 1 – a view from Drosophila

Dr. Nadia Naffakh

Affiliation: Institut Pasteur, CNRS (France)
Title: Biochemical and structural analysis of the spliceosomal RED-SMU1 complex and its interaction with influenza A virus RNA polymerase

Dr. Eduardo Bagagli

Affiliation: Sao Paulo State University (UNESP) (Brazil)
Title: Intein PRP8 in pathogenic fungi: evolutionary aspects and splicing evaluation

Dr. Eric van der Veer

Affiliation: Leiden University Medical Center (Netherlands)
Title: Quaking post-transcriptionally promotes differentiation of monocytes into pro-atherogenic macrophages by controling pre-mRNA splicing and mRNA abundance

Dr. Sachiyo Kawamoto

Affiliation: National Institutes of Health (USA)
Title: Diverse isoforms of Rbfox family proteins and their splicing activities

Dr. Stuart Ralph

Affiliation: The University of Melbourne (Australia)
Title: Regulation of alternative splicing in human parasites

Dr. Christine Vande Velde

Affiliation: Universite de Montreal, CHUM Research Center (Canada)
Title: RNA binding proteins in amyotrophic lateral sclerosis

Dr. Karen Doggett

Affiliation: Development and Cancer Division, Walter and Eliza Hall Institute of Medical Research (Australia)
Title: Essential Roles for Minor Class Splicing in Development and Cancer

Dr. Miloslava Fojtova

Affiliation: Central European Institute of Technology (CEITEC), Masaryk University (Czech Republic)
Title: Fate of plant TERT genes in polyploids in relationship with their evolution, genomic and splicing variants

Dr. Cara Shirai

Affiliation: Washington University in St. Louis (USA)
Title: Biologic and Therapeutic Implications for U2AF1 Mutations in Blood Cancers

Dr. Jacqueline Cloos

Affiliation: VU University Medical Center, Cancer Center Amsterdam (The Netherlands)
Title: SoonAlternative splicing in acute leukemia: the relevance for drug resistance and treatment

Dr. Michele Mishto

Affiliation: Universitätsmedizin Belin Charite (Germany)
Title: Mechanisms and immunological relevance of proteasome-catalysed peptide splicing

Dr. Klaus Holzmann

Affiliation: Medical University Vienna, Comprehensive Cancer Center (Austria)
Title: Epithelial splicing regulatory proteins ESRP1 and ESRP2 correlate with splice signatures and outcome in human colorectal cancer

Dr. Cameron Mackereth

Affiliation: Institut Europeen de Chimie et Biologie, Inserm U1212, University of Bordeaux (France)
Title: Molecular details of muscle-specific alternative splicing in C. Elegans

Dr. Jonàs Juan-Mateu

Affiliation: ULB Center for Diabetes Research, Université Libre de Bruxelles (Belgium)
Title: Regulation of pancreatic beta cell function and survival by alternative splicing: the role of the splicing factor SRp55

Dr. Lisa Henning

Affiliation: Insitute for Chemistry and Biochemistry, Freie Universität Berlin (Germany)
Title: Towards a role of the multivalent adaptor protein FBP21 during splicing

Dr. Laurent Corcos

Affiliation: INSERM U1078-ECLA, Faculty of Medicine (France)
Title: Splicing alterations in colon cancer progression

Dr. Jonathan Hall

Affiliation: Swiss Federal School of Technology (ETH) Zurich, Institute of Pharmaceutical Sciences (Switzerland)
Title: A Splice-Correcting Strategy for Ferrochelatase

Dr. Alexandra Moreira

Affiliation: IBMC – i3S (Portugal)
Title: Regulation of CD6 alternative splicing during T cell activation

Dr. Oriane Mauger

Affiliation: University of Basel (Switzerland)
Title: Neuronal activity regulates splicing of retained intron-containing transcripts

Dr. Olatz Villate

Affiliation: BioCruces Health Research Institute (Spain)
Title: Splicing disrupting mutations in intellectual disability

Dr. Cyril Dominguez

Affiliation: Department of Molecular and Cell Biology,University of Leicester (UK)
Title: Specific G-quadruplex ligands regulate the alternative splicing of Bcl-x

Dr. Joel Neilson

Affiliation: Baylor College of Medicine (USA)
Title: CELF1 is a central node in post-transcriptional regulatory programs underlying EMT

Dr. Lynne-Marie Postovit

Affiliation: Baylor College of Medicine (USA)
Title: Novel alternative splicing of the embryonic morphogen Nodal is regulated by a common genetic variation in chromosome 10 q22.1: Implications for a strong sex bias and XIST regulation in human embryonic stem cell lines

Dr. Brian Oliver

Affiliation: National Institutes of Health (USA)
Title: Validation of transcript annotations using simulation, comparative genomics, and deep transcription profiling

Dr. Richard Padgett

Affiliation: Cleveland Clinic (USA)
Title: Spliceosomal snRNA Mutations in Human Diseases

Dr. Marie Öhman

Affiliation: The WennerGren Institute, MBW Stockholm University (Sweden)
Title: Distant cis acting intronic elements induce exonic RNA editing

Dr. Hui Li

Affiliation: University of Virginia (USA)
Title: Intergenic splicing in cancer and normal physiology

Dr. Birgit Strobl

Affiliation: Institute of Animal Breedings and Genetics, University of Veterinary Medicine Vienna (Austria)
Title: Alternatively spliced isoforms of STAT1 in cytokine signaling and immunity

Dr. Jeffrey Toretsky

Affiliation: Georgetown University (USA)
Title: Oncogenesis through splicing leads to therapeutic opportunity

Dr. Charles Chalfant

Affiliation: Virginia Commonwealth University (USA)
Title: Gain-of-function splice variants of apoptotic and stress factors drive cancer cell signaling and provide new paradigms in transcriptional regulation

Dr. Miguel Thomson

Affiliation: Instituto de Salud Carlos III (Spain)
Title: Frequent in vivo detection of HIV-1 RNAs of the 1 kb class using diverse 3’ splice sites

Dr. Eulàlia de Nadal

Affiliation: Universitat Pompeu Fabra (Spain)
Title: Role of the p38 MAPK in the regulation of Alternative Splicing

Dr. David Stanek

Affiliation: Institute of Molecular Genetics (Czech Republic)
Title: Molecular principles of snRNP surveillance in the Cajal body

Dr. Alexander Wolf

Affiliation: Institute of Molecular Toxicology & Pharmacology, Helmholtz Zentrum Muenchen (Germany)
Title: The oxygenase Jmjd6 – a master regulator of SR-proteins?

Dr. Lucy Donaldson

Affiliation: University of Nottingham (UK)
Title: Inhibitors of alternative splicing as novel analgesics

Dr. Giuseppina Lacerra

Affiliation: Institute of Genetics and Biophysics “A.Buzzati Traverso” (Italy)
Title: Towards a complete definition of the thalassemia defect: molecular characterization of new splicing mutants

Dr. Peter Jordan

Affiliation: Department of Human Genetics, National Health Institute ‘Dr. Ricardo Jorge’ (Portugal)
Title: Tumor-related alternative splicing variant RAC1b in colorectal cancer: regulation and role in tumorigenesis

Dr. Nouar Qutob

Affiliation: Weizmann Institute of Science (Israel)
Title: The relevance of somatic synonymous mutations in melanoma

Dr. Gloria Despacio-Reyes

Affiliation: Wellcome Trust Sanger Institute (UK)
Title: Producing high quality gene annotation for human and other vertebrates

Dr. Zsuzsanna Izsvák

Affiliation: Max Delbruck Center for Molecular Medicine (Germany)
Title: Endogenized Transposable Elements Reshape the Human Transcriptome

Dr. Federico Calegari

Affiliation: Dresden University of Technology (Germany)
Title: Alternative splicing in neurogenic commitment during brain development

Dr. Nelson Tang

Affiliation: The Chinese University of Hong Kong (Hong Kong)
Title: Splicing aberration in SLC25A13 gene with tissue specificity

Dr. Rodrigo Prado-Martins

Affiliation: Inserm UMR1162, Université Paris (France)
Title: BPre-mRNA events decide translation initiation efficacy

Dr. Loydie Jerome-Majewska

Affiliation: McGill University (Canada)
Title: Expression of Esrp1 and Esrp2 During Placental Development

Dr. Iraida Sharina

Affiliation: UTHealth McGovern Medical School (USA)
Title: Splicing as a modulator of function of Nitric Oxide receptor soluble guanylyl cyclase

Dr. Alexandra Martins

Affiliation: Inserm-U1079-IRIB, University of Rouen (France)
Title: Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools

Dr. Brage Andresen

Affiliation: University of Southern Denmark (Denmark)
Title: Blocking of iCLIP identified hnRNPA1 binding sites by splice switching oligonucleotides corrects aberrant splicing

Dr. Laura Elnitski

Affiliation: National Human Genome Research Institute, NIH (USA)
Title: Functional Disruption of mRNA Splicing in Cancer Revealed through Predictive and Transcriptomic Analyses

Dr. Rita Brandão

Affiliation: Maastricht University (The Netherlands)
Title: Splicing events in tumour suppressor genes using targeted RNA-seq

Dr. Gennady Churakov

Affiliation: Westfälische Wilhelms-Universität (Germany)
Title: Environmental temperature and its impact on the process of programmed DNA elimination in Paramecium

Dr. Jan Ševcík

Affiliation: Charles University in Prague (Czech Republic)
Title: A complex characterization of BRCA1 alternative splicing pattern in different tissues of healthy and breast cancer individuals

Dr. Alison Tyson-Capper

Affiliation: Newcastle University (UK)
Title: What are the translational implications of alternative splicing events in breast cancer?

Dr. Aurélie Baguet

Affiliation: COMUE University of Bourgogne Franche-Comté (France)
Title: Perispeckles: subnuclear territories enriched in EJC-bearing mRNAs

Dr. Valer Gotea

Affiliation: National Human Genome Research Institute, NIH (USA)
Title: The Functional Impact of Mutations Induced by Ultraviolet Radiation in Melanoma

Dr. Jennifer Batson

Affiliation: NExonate Ltd (UK)
Title: Novel SRPK1 inhibitors potently and selectively inhibit SRPK1-regulated VEGF-A alternative splicing with properties to control angiogenesis in vivo